The Dalai Lama was born Lhamo Thondup on July 6, 1935 in Taktser, China, to a peasant family. At age 15, he assumed political power of Tibet as the Dalai Lama. The People's Republic of China invaded that same year. Fearing assassination, he and thousands of followers fled to Dharamsala in northern India, where they established an alternative government. Since then, the Dalai Lama has taken numerous actions in hopes of establishing an autonomous Tibetan state within the People's Republic of China. However, the Chinese government has shown no signs of moving toward peace and reconciliation with Tibet. The Dalai Lama has also conducted hundreds of conferences, lectures and workshops worldwide, as part of his humanitarian efforts. He was awarded the Nobel Peace Prize in 1989. In December 2008, the Dalai Lama announced his semi-retirement after having gallstone surgery.

He is the head of state and spiritual leader of the Tibetan government-in-exile based in Dharamshala, India. Tibetans believe him to be the reincarnation of his predecessors. For nearly 50 years, he had aimed to establish Tibet as a self-governing, democratic state.

Lhamo Thondup was the fifth of 16 children—seven of whom died at a young age. After several months of searching for a successor to the 13th Dalai Lama and following many significant spiritual signs, religious officials located Lhamo Thondup, at age 2, and identified him as the reincarnation of the 13th Dalai Lama, Thubten Gyatso. Young Lhamo was renamed Tenzin Gyatso and proclaimed the 14th Dalai Lama.

Dalai Lamas are believed to be the reincarnation of Avalokitesvara, an important Buddhist deity and the personification of compassion. Dalai Lamas are also enlightened beings who have postponed their own afterlife and chosen to take rebirth to benefit humanity. "Dalai" means "ocean" in Mongolian (the name "Gyatso" comes from the Tibetan word for ocean). "Lama" is the equivalent of the Sanskrit word "guru," or spiritual teacher. Put together, the title of Dalai Lama is literally "Ocean Teacher," meaning a "teacher spiritually as deep as the ocean."

Tenzin began his religious education at age 6. His schooling consisted of logic, Tibetan art and culture, Sanskrit, medicine and Buddhist philosophy, which is divided into five other categories dealing with the perfection of wisdom, monastic discipline, metaphysics, logic and epistemology—the study of knowledge. At age 11, Tenzin met Heinrich Harrer, an Austrian mountaineer, who became one of his tutors, teaching him about the outside world. The two remained friends until Harrer's death in 2006.

In 1950, at the age of 15, Tenzin assumed full political power as the Dalai Lama. However, his governorship was short. In October of that year, the People's Republic of China invaded Tibet against little resistance. In 1954, the Dalai Lama went to Beijing for peace talks with Mao Zedong and other Chinese leaders. However, in 1959, continued suppression of the Tibetan people by Chinese troops led to their uprising. The Dalai Lama and his closest advisers believed the Chinese government was planning to assassinate him. Consequently, he and several thousand followers fled to Dharamshala in northern India and established an alternative government there.

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